Dr Jianhua Guo
The University of Queensland, Australia
Abstract: When we think of antibiotic resistance, we often link it to the intensive use of antibiotics for medical, veterinary or agricultural purposes. Although non-antibiotic pharmaceuticals and chemicals are widely used in our daily life, little is known about their contribution to the spread of antibiotic resistance. We are wondering if non-antibiotic chemicals are playing a role, invisibly.To address this question, we have established a series of bacterial models, including mutation and horizontal gene transfer at both single-cell level and community level. Indeed, we found common non-antibiotic chemicals, such as artificial sweeteners can accelerate the spread of antibiotic resistance. We also employed interdisciplinary methods (including molecular biology, genetic, various omics and mathematical modeling) to reveal underlying mechanisms.This seminar will deliver our recent discoveries that artificial sweeteners can speed up the spread of antibiotic resistance. They are invisible or neglected factors for antibiotic resistance, like all icebergs lying underwater.
Host：Prof. Yi Luo
Nanjing University
Time：9:00am June 25, 2022 (Beijing time)
Zoom ID: 816 9975 7155
Bilibili: 25002335
